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For tablet:
- Weigh individually twenty units taken at random or, for single-dose preparations presented in individual containers the contents of twenty units, and determine the average mass.
- Not more than two of the individual masses deviate from the average mass by more than the percentage deviation shown in table 1 and none deviates by more than twice that percentage.
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Powders for parenteral use:
- Remove any paper labels from a container and wash and dry the outside.
- Open the container and without delay weigh the container and its contents.
- Empty the container as completely as possible by gentle tapping, rinse it if necessary with water R and alcohol R and dry at 100 °C to 105 °C for 1 h.
- If the nature of the container precludes heating at this temperature, dry at a lower temperature to constant mass.
- Allow to cool in a desiccator and weigh.
- The mass of the contents is the difference between the weighing.
- Repeat the procedure with another 19 containers.
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Uniformity of weight (mass) of delivered doses from multi-dose containers:
- The following test is intended for oral dosage forms such as granules, powders for oral use and liquids for oral use, which are supplied in multi-dose containers fitted with an integral measuring device.
- Weigh individually twenty doses taken at random from one or more containers with the integral measuring device.
- Determine the individual and average weights (masses).
- Not more than two of the individual weights (masses) deviate from the average weight (mass) by more than 10% and none deviates by more than 20%.
